Most of the high protein in urine alone is caused by nephritis, whether it is acute nephritis, acute-progressive nephritis, or chronic nephritis and secondary nephritis, such as purpura nephritis, lupus nephritis, diabetic nephropathy and so on, the glomerular filtration membrane is damaged, the permeability is increased, and the loss of protein from here forms proteinuria. In addition to the symptoms of proteinuria, some patients also have edema and elevated blood pressure. Secondary nephritis also has manifestations of underlying diseases, such as diabetes, lupus and purpura. In addition to these kidney diseases can lead to high urine protein, some physiological factors can also lead to increased urine protein, such as checking the urine routine after strenuous exercise, or checking the urine routine before the symptoms of fever, these physiological factors removed after the disappearance of urine protein, generally do not need special treatment, only the pathological factors need to be based on the cause of the treatment.