Amoxicillin capsules do not have a therapeutic effect when the penis is engorged with blood for a long period of time leading to scrotal distension and pain, which can be relieved by proper rest. If the symptoms are not relieved after rest, it is recommended to consult a doctor to take medication under the guidance of a physician. Penis long time congestion and cause scrotal distension is due to the local blood in the penis and scrotum part of the long-term stay and cause obstruction symptoms, belong to the normal physiological phenomenon. Generally, after the penile congestion symptoms have been effectively relieved, the swelling and pain in the scrotum area will gradually disappear, and appropriate rest can be effectively relieved, without the need for special medication. If not relieved, it is recommended to consult a doctor in time. Amoxicillin capsules are mainly used for the treatment of inflammation or infection symptoms, can relieve common bacterial infections caused by respiratory tract infections or urinary tract infections, can help to relieve the symptoms of inflammation. Common adverse reactions to taking Amoxicillin are diarrhea, nausea and rash. Penicillin is contraindicated in patients with penicillin allergy and positive penicillin skin test. It is contraindicated in persons with severe rapid-onset hypersensitivity reactions (e.g., anaphylactic reactions) to other -lactam agents (e.g., cephalosporins, carbapenems, monocyclic -lactams). However, in the absence of significant inflammation or bacterial infection, amoxicillin capsules have no significant therapeutic effect on symptoms such as congestion. Therefore scrotal distension caused by penile congestion cannot be treated with Amoxicillin capsules. After a long period of penile congestion and scrotal distension, you can properly relax the external genitalia and rest, can help to relieve, do not take medication without authorization.