Blisters are known as blisters. The appearance of many small blisters on the hands may be due to hand, foot and mouth disease, sweat herpes, hand eczema and other factors, can be relieved by general treatment, medication and other methods. 1. Hand, foot and mouth disease: this is due to enterovirus infection caused by acute fever rash disease, there is no treatment of the virus drugs and specific treatment means, can cooperate with the doctor to choose interferon and other antiviral drugs, so as to shorten the course of the disease. 2. Sweat herpes: due to local allergies, local infections, excessive sweating, etc., thus appearing on the hands of sweat herpes symptoms, manifested as a lot of small blisters on the hands, after diagnosis, you can cooperate with the doctor to use topical tretinoin urea ointment, hydrocortisone butyrate ointment and other drugs. 3. Hand eczema: hand eczema patients, will also cause localized pimples, papules, blisters phenomenon, can cooperate with the doctor to choose hydrocortisone cream, dexamethasone cream and other glucocorticosteroid drug treatment. At the same time can be combined with oral antihistamine drugs such as loratadine. In addition, you need to try to find the causative factors and get rid of them. Drugs need to be used under the guidance of a doctor, not blindly self-medication, in order to avoid adverse effects. Patients are advised to go to the hospital in time and follow the doctor’s instructions for standardized treatment.