Swelling and pain in the thumb may be caused by purulent dactylitis, rheumatoid arthritis, hyperuricemia and so on. 1. Purulent dactylitis: this disease mainly refers to the subcutaneous tissue of the palm surface of the finger terminal septic infection, most of the finger trauma or nail groove inflammation does not heal due to, can be under the guidance of the doctor, through the use of drugs such as clindamycin hydrochloride treatment, but also through surgery, such as incision and drainage, if the pus cavity is relatively large, need to be inserted into the latex sheet drainage. 2. Rheumatoid arthritis: it can be treated by using drugs such as methotrexate, penicillin, cyclosporine, trimethoprim and so on under the guidance of doctors, and also by surgery in serious cases. 3. Hyperuricemia: the disease is a metabolic syndrome caused by purine metabolism disorders, can be under the guidance of the doctor, through the treatment of drugs, such as allopurinol, febuxostat, chlosartan and so on. It is recommended that patients go to the hospital, under the diagnosis of the doctor, according to the patient’s specific condition, to take targeted treatment. The use of the above drugs must be in accordance with medical advice.