The hepatitis B vaccine is valid for about 10 years after injection. After 10 years of hepatitis B vaccination, the hepatitis B surface antibody in the patient’s body will be slowly depleted. If the hepatitis B surface antibody is negative or the titer is less than 10 mIU/mL, the patient should consider actively receiving the hepatitis B vaccine for booster. If the titer is more than 10mIU/mL and positive, it is recommended that the patient continue to observe the vaccination. Patients should pay attention to active prevention and not to contact with unexplained blood or body fluids. If there is a patient with chronic viral hepatitis B in the family, the razor, toothbrush, utensils, etc. should be moderately isolated and open wounds should be avoided to avoid contact with the patient’s blood.