Antimicrobials, or other drugs, can be administered by puncture from a vein in the dorsum of the hand through a network of superficial veins in the dorsum of the hand into the veins of the vital veins, and then to the axillary vein, the subclavian vein, the superior vena cava, the right atrium, the right ventricle through the pulmonary circulation into the left atrium, and the left ventricle deeper into the aorta, further to the descending aorta, then the abdominal aorta, and then to the appendicus, and then the superior mesenteric artery, and then the ileococaecal artery, before reaching the appendix artery. . In particular, antimicrobials pass through this circulatory pathway and are localized to be able to control acute simple appendicitis, and some pathologies can lead to vasospasm or thromboembolism, which can affect drug circulation and transit to some extent.