Cold with headache can be appropriate to take ibuprofen, ibuprofen has antipyretic and analgesic effect. Ibuprofen can inhibit the synthesis of prostaglandins, with antipyretic, analgesic, anti-inflammatory effect, clinically used in the treatment of toothache, headache and other pain, as well as colds caused by fever symptoms. Ibuprofen can be taken to relieve headache or reduce fever when a cold is accompanied by headache and fever. Ibuprofen is contraindicated in people who are allergic to non-steroidal anti-inflammatory drugs, pregnant and lactating women, and cannot be used for the treatment of perioperative pain in coronary artery bypass grafting surgery, and should not be used in patients with peptic ulcer. Use may cause gastrointestinal discomfort, nausea and vomiting, headache, tinnitus and other adverse reactions. It should be used under the guidance of a physician or pharmacist. Patients with cold and flu are advised to seek prompt medical attention if their symptoms continue to be unimproved or even worsen.