The invasion of bone marrow by B-cell lymphoma represents that the lymphoma has entered stage IV, which needs to be actively treated to improve the survival. Stage IV B-cell lymphoma is mainly treated with radiotherapy, and the drugs include epothilone, cyclophosphamide, etc. The survival rate is about 20~30% within five years, and can be supplemented with rituximab treatment if necessary, which can significantly improve the survival period. The common clinical types of B-cell lymphoma include diffuse large B-cell lymphoma, follicular lymphoma, condylomatous lymphoma, small-cell lymphoma, etc. The treatment is mainly based on chemotherapy, which can be supplemented by the targeting drug Merovia, in addition, autologous hematopoietic stem cell transplantation is also a good treatment method. Patients should pay attention to the diet structure, pay attention to personal hygiene and cleanliness, and take a light, high protein diet. The use of medication under the guidance of a physician.