The following treatment measures can be given for cough and sputum that cannot be coughed out: i. Application of phlegm-suppressing drugs, such as oral aminoglutethimide and N-acetylcysteine for treatment, and nebulized inhalation of N-acetylcysteine can also be given to promote the patient’s sputum excretion. If the patient also has airway spasm, nebulized inhalation of bronchodilator can be given to promote the patient’s sputum excretion. Second, sputum can be promoted by turning, back tapping, vibration and postural drainage. Fiberoptic bronchoscopy can not only remove the secretions in the airways, but also can be used to obtain specimens for sputum culture and other related examinations to further clarify the pathogenic diagnosis and guide the application of antibiotics. Fourth, if there is a combination of respiratory failure, it is also necessary to give tracheal intubation to keep the airway open and give mechanical ventilation to correct the patient’s respiratory failure.