The following table compares the major adverse effects and effective dose ranges of commonly used antipsychotic drugs for your reference.
Classification and drug name Excessive sedation Postural hypotension Anticholinergic effects Extrapyramidal symptoms Dose range
First-generation antipsychotics
Chlorpromazine High High Medium Medium 25-600 mg/day
Endorphin Low Low Low Low Medium 4 to 40 mg/day
Trifluoperazine Low Low Low High 5 to 45 mg/day
Fluphenazine Low Low Low High 2 to 30 mg/day
Fluphenazine decanoate Low Low Low High 12.5~50mg/2~3 weeks
Chlorprothixene High High Medium Medium 50～600mg/day
Flupentixatron decanoate
Injection Low Low Low Low High 20/2～3weeks
Chlorprothixene Medium Medium Medium Medium High 5～40 mg/day
Haloperidol Low Low Low High 2～40 mg/day
Haloperidol decanoate
Injection low low low low high 50 to 100 mg/2 to 4 weeks
Pentoxifylline Low Low Low High 20～120mg/week
Sulpiride Low Low Low Low Medium 200～1200 mg/day
Piperothiazide palmitate
Injection Low Low Low Low High 50～200mg/2～4 weeks
Second-generation antipsychotics
Risperidone low low low low 1-10 mg/day
Ziprasidone Low Medium Low Low Low 40 to 160 mg/day
Clozapine High High High Low 25-600 mg/day
Olanzapine Medium Medium Medium Low 5-20 mg/day
Quetiapine High Medium Medium Low 150-800 mg/day
Aripiprazole low, medium, low, low 5-30 mg/day
Amisulpride low, medium, low, medium 50-1200 mg/day
Paliperidone low, medium, low, medium 3-12 mg/day
For injection
Risperidone microspheres Low Medium Low Medium 25～50mg/2 weeks
Paliperidone palmitate
Injection Low Medium Low Low Medium 25～150mg/month