Leather stomach will finally develop into a serious condition of late gastric cancer, which may appear a series of symptoms, including local symptoms and systemic symptoms. 1. Local symptoms: in the advanced stage of leather stomach, there are pain in upper abdomen, obvious abdominal distension, decreased appetite, bleeding tendency, large amount of vomiting blood, black stool, difficulty in swallowing, enlarged liver, ascites, etc. Bone metastasis is accompanied by pain in bone joints and even limitation of joint movement. Bone metastasis is accompanied by pain in bones and joints, and even restriction of joint movement. 2. Systemic symptoms: can be manifested as extreme lethargy, fatigue, low fever persists, mental depression, even lethargy and coma state, serious will cause multi-organ failure and death. Leather stomach should be treated under the guidance of a doctor, and strive to control the progress of the disease, and improve the symptoms.