What to do if the fever comes back 6 hours after ibuprofen has reduced the fever? Depending on how high the fever has gone again and the dosage form of ibuprofen, consideration should be given to whether to give physical cooling or to take fever-reducing medication again. Patients with a fever of 38.5°C or higher or significant discomfort due to fever may be given an antipyretic such as ibuprofen. The immediate-release form of ibuprofen (e.g., ibuprofen tablets) has a half-life of about 2 hours and a duration of action of about 6 hours, and the extended-release form of ibuprofen (e.g., ibuprofen extended-release capsules) has a half-life of 4 to 6 hours and a duration of action of up to 12 hours. 1. If the patient takes ibuprofen for fever and then has fever after 6 hours, the temperature can be given to drink more water or warm water wipe to lower the physical temperature if the temperature is below 38.5℃ and there is no discomfort. 2. If the body temperature reaches 38.5℃ or above or if there is obvious discomfort due to fever, appropriate treatment should be given according to the ibuprofen dosage form taken: (1) If ibuprofen tablets are used, repeat the administration once with hydration. (2) If ibuprofen extended-release capsules are used, hydration may be given, physical hypothermia may be given, and the body may be observed for a period of time to see if the temperature drops. If the body temperature is higher than before ibuprofen was used, it should be taken to hospital urgently for treatment. When fever occurs, medication should be used under the guidance of a medical professional, and antipyretics should not be used on their own at the expense of other treatments.