The treatment of interstitial fibrosis includes removing the cause of the disease, treating the primary disease, antiviral drug therapy, non-pharmacological treatment, lung transplantation, and treatment of comorbidities. 1. Remove the cause of the disease: For secondary interstitial fibrosis, we should avoid exposure to and actively deal with the triggering factors, such as staying away from occupational environments such as dust and nitrogen oxides. 2. Treatment of primary disease: recurrent episodes of primary disease can lead to worsening of interstitial fibrosis, and the primary disease should be actively treated. For example, autoimmune diseases such as systemic lupus erythematosus can be treated with glucocorticosteroids (e.g., prednisone) and immunosuppressants (e.g., cyclophosphamide). 3. Anti-fibrotic drug therapy: Pirfenidone and Nidazanib can be given to anti-fibrotic therapy, and evidence-based medical evidence proves that they can slow down the decline of interstitial fibrosis lung function. 4. Non-pharmacological treatment: patients with significant hypoxemia in the resting state should be given long-term oxygen therapy, but idiopathic interstitial fibrosis caused by expiratory failure is generally not recommended to use mechanical ventilation. Patients should also undergo pulmonary rehabilitation as much as possible. 5. Lung transplantation: it is the most effective treatment for end-stage interstitial fibrosis, but there are strict indications and contraindications, and it is still difficult to carry out widely. 6. Treatment of comorbidities: antibiotics can be used to control the infection if it is combined with intrapulmonary infection. Combined with spontaneous pneumothorax, emphysema, pulmonary hypertension, pulmonary heart disease, hemoptysis, etc. should be actively treated. Specific treatment programs need to go to the regular hospital in a timely manner, follow the doctor’s instructions, in order to better treat the disease.