Obstructive hypertrophic cardiomyopathy (HCM) is named for the progressive hypertrophy of the heart muscle, and Steve ROmmen from the Mayo Clinical Center noted in an interview with HeartWire, “The disease has an incidence of about 1 in 500 in athletes and is the leading cause of death in young athletes. It is genetically linked and the average age of diagnosis is between 30-40 years old. Usual symptoms include shortness of breath, chest tightness, and in severe cases, a mild headache. A heart murmur can be detected on physical examination, plus an electrocardiogram may show abnormalities. Left ventricular outflow tract (LVOT) obstruction is an important indication for surgery in HCM, and septal resection repair removes the muscle mass in the septum that interferes with blood flow. This procedure has been performed at the Mayo Clinical Center for many years and is considered the best treatment for symptomatic relief, but its impact on survival and mortality is not known. The aim of this study is to clarify whether this procedure can prolong survival. The surgical resection group all showed improvement in clinical symptoms, with a total of 255 (89%) patients having a NYHA classification of 3-4 before surgery, compared to only 12 (6%) such patients after surgery. The mortality rate in the operated group was not significantly different from that of the non-obstructed group, and in addition, the difference in age and sex did not affect the mortality rate. Patients in the surgical group had a higher survival rate compared to patients with non-surgical but obstructive HCM. At 10 years of age, 39% of patients with nonoperated obstructive HCM died, but the mortality rate in the operated group was only 17%. The current study provides ample evidence for the advantages of surgery in the treatment of obstructive hypertrophic cardiomyopathy, the optimal time for surgery is when the patient is still young, all patients with indications for septal resection can benefit from surgery, it not only improves quality of life, but also prolongs survival, therefore even asymptomatic or minimally symptomatic patients should be operated on, and surgery at least does not make the survival to continue to deteriorate; rather, it usually allows patients to live longer.