Hypertrophic obstructive cardiomyopathy has always been a difficult clinical problem. In recent years, interventional methods have provided new directions and means for the treatment of this disease. The Department of Cardiology of Baikou’en International Peace Hospital, under the leadership of Director Wang Dongmei, successfully completed the first case of septal chemical ablation for hypertrophic obstructive cardiomyopathy on February 23, 2014, which can alleviate the clinical symptoms of the patients, make the septum thinner, reduce the obstruction of left ventricular outflow tract, and relieve the pain of the disease by preventing sudden death. Hypertrophic obstructive cardiomyopathy is easy to be misdiagnosed clinically, and easy to be accompanied by angina pectoris, syncope sudden cardiac death. In the past, hypertrophic obstructive cardiomyopathy was mainly relieved by some medication, but it could not prevent the disease from continuing to progress, and patients would often die suddenly due to severe obstruction of the left ventricular outflow tract, arrhythmia, and heart failure. Doctors are at their wits’ end. In view of the great threat to the patient’s life, Wang Dongmei, director of the Department of Cardiology at Baiqiu’en International Peace Hospital, was the first in the province to perform chemical ablation for a 63-year-old male patient. The patient, who was hospitalized for sudden syncope, had asymmetric thickening of the interventricular septum, reduced left ventricular outflow tract, and a pressure step difference of 130 mmHg in the left ventricular outflow tract, and was at risk of sudden death without active treatment. Under the guidance of Prof. Wang Shouli of Hospital 306 and the active cooperation of ultrasonographers, chemical ablation of the interventricular septum was performed. First of all, left ventricular angiography and left ventricular outflow tract manometry were performed to determine that there was a narrowing of the left ventricular outflow tract, which was confirmed to be suitable for interventional therapy, and then coronary angiography was performed to observe the size and alignment of the vessels of the first septal branch or the second septal branch, and it was determined that the vessels of the first septal branch or the second septal branch were clear, and that the area of the blood supply area was a hypertrophied part of the myocardium, which was anatomically suitable for the chemical ablation procedure. Next, 95% ethanol was selectively injected through the catheter into the vessels of the first septal branch, resulting in occlusion of the vessels and blocking their blood supply. After the procedure, the patient’s murmur was significantly reduced, the pressure gradient of the left ventricular outflow tract decreased to 30 mmHg, and the contraction of the hypertrophied septal myocardium was weakened and the left ventricular outflow tract was widened by ultrasonography. At present, the patient’s condition is stable, and no serious complications such as large myocardial infarction, third-degree atrioventricular block and other malignant arrhythmias have occurred. He will be discharged electively within 1 week.