Many parents ask whether children with epilepsy can be vaccinated. This question is of great concern because many domestic vaccine instructions indicate that it is contraindicated in children with epilepsy. Unfortunately, however, there are no guidelines that simply answer yes or no. In the 2013 edition of the latest version of the Immunisation against infectious disease, the Green Book, published by Public Health England, it is mentioned that epilepsy is not a contraindication to vaccination per se. Neurological side effects following vaccination in patients with epilepsy have occurred occasionally, but are not statistically significant. Vaccinations are effective in ensuring the health of the vast majority of children, so children should not be denied potentially life-saving vaccines. Some vaccinations cause an increase in body temperature, commonly the B encephalitis vaccine, the rheumatoid brain vaccine, and the white bacillus vaccine. When the child has a family history of epilepsy, febrile convulsions, or seizures, the vaccination may induce seizures or aggravate them, but there are no significant side effects on long-term follow-up, so normal vaccination is still recommended. However, for children with certain congenital defects that have not yet developed before vaccination, vaccination may induce seizures, unpredictable accidents, or even sudden death. Organic aciduria, mitochondrial disease, fatty acid metabolism disorders, and urea cycle disorders can start acutely under stressful conditions such as fever, fatigue, drugs, starvation, and disease. These diseases are usually due to genetic or inherent defects, which means that even without vaccination, they will develop sooner or later the next time they are exposed to fever, starvation or trauma. If these problems are not recognized, doctors may diagnose the disease as “meningitis” and parents may misinterpret it as “vaccination has made the child stupid and killed him. The current opinion of our center is: if seizures are rare, or if seizures are completely controlled within 1 year, we will explain the pros and cons to the family and recommend vaccination. Children with epilepsy who have seizures that are not controlled should not receive a booster vaccination; children with epilepsy who have convulsions within 3 days after the first vaccination should not receive a booster vaccination; children who have encephalopathy within 7 days after the first vaccination should not receive a second vaccination; children with frequent seizures or progressive encephalopathy of unknown origin are advised to hold off.