The causes of nose acne include genetics, androgen secretion, Propionibacterium acnes infection, and immune-inflammatory response. 1. The cause of acne is related to heredity and is caused by increased sebum secretion due to increased androgen levels or imbalance between male and female hormone levels during puberty. 2. Propionibacterium acnes hydrolyzes the triglycerides in sebum to free fatty acids, which stimulates the proliferation and hyperkeratosis of keratinocytes in the ducts of hair follicles, which blocks sebum excretion and clogs pores, forming acne. 3. After the skin is infected with Propionibacterium acnes, it also produces pro-inflammatory factors through a complex reaction, causing an immune-inflammatory response, thus causing acne. If a patient develops nose acne, it is recommended that he or she seek medical attention and treatment under the guidance of a doctor.