There is a kind of stomach pain caused by drugs, so it is called “pharmacogenic gastroparesis”, that is, after taking certain drugs, there will be pain in the stomach, acid reflux and loss of appetite and other discomfort. For this type of stomach pain, it’s not just a matter of taking painkillers or stomach medicine, but of adjusting your medication habits and methods. “Pharmacogenic gastroparesis” is mainly caused by drugs that stimulate the gastric mucosa to varying degrees, which in turn causes gastric mucosal congestion and erosion. The drugs that tend to cause “pharmacogenic gastroparesis” are mainly non-steroidal drugs or anticoagulants, such as aspirin. In particular, patients with coronary heart disease often need to take aspirin for a long time because of their condition, in order to avoid “pharmacogenic gastroparesis”, doctors often recommend that patients take it after meals, and at the same time add gastric mucosal protective agents, and ferrous sulfate, doxycycline, etc. can be taken after meals. In fact, “pharmacogenic gastrointestinal disease” is completely preventable. Director Shang gave three tips: first, chronic patients with sudden onset of acute disease, should first take drugs that can relieve acute disease. For example, if a coronary heart patient is combined with acute gastritis, it may be worthwhile to stop the treatment of heart disease aspirin first, first take the treatment of acute gastritis drugs. This is because aspirin takes a long time, while the treatment of acute gastritis drugs generally only need to eat 2 to 3 days, which can reduce the “pharmacogenic gastric disease” attack. The second thing is to choose an alternative medicine. For example, change the aspirin into enteric tablets; not suitable for taking the compound blood pressure tablets containing lisinopril, under the guidance of a doctor can be replaced by other antihypertensive drugs, so as to ensure the effectiveness of the drug, but also to reduce the damage to the stomach and intestines. Third, to reduce the drug on the gastric mucosa irritation, you can also switch to an aqueous solution. For example, 10 ml of potassium chloride solution (10% concentration) is equivalent to 1 gram of potassium chloride tablets, if taken on an empty stomach before a meal, while paying attention to drinking more water, the drug can enter the duodenum through the stomach in a few minutes, or the drug can be dissolved in milk and diluted. Shang Zhanmin, Department of Gastroenterology, Beijing Chaoyang Hospital