Immunotherapy is a treatment method that improves abnormalities in the body’s immune function by artificially enhancing or suppressing the body’s immune function. Possible side effects are skin damage, gastrointestinal discomfort, fever, and infections. 1. Skin damage: When immunotherapy is administered, it may lead to the emergence of immune tolerance in patients, which in turn may damage the skin barrier, thus causing patients to display symptoms such as rashes and purpura. 2. Gastrointestinal discomfort: when patients undergo immunotherapy, it may lead to abnormal intestinal flora or T-cell gastric mucosal infiltration, which may lead to gastrointestinal discomfort such as loss of appetite, abdominal pain, diarrhea and other symptoms. 3. Fever: immunotherapy may also cause the body to develop fever, which may be accompanied by headache, sore throat and other symptoms. 4. Infection: The application of certain immunotherapy may lead to infection or aggravation of existing infections. In addition, immunotherapy may cause depression and fatigue. If you experience any discomfort during immunotherapy, it is recommended that you seek medical attention in a timely manner and carry out the treatment under the guidance of your doctor.