Calf pain when squatting down may be physiological factors, such as exercise is too intense, there may also be pathological reasons, such as muscle strain, strains, etc., for different causes of calf pain relief are different, need to be symptomatic treatment for specific symptoms. If it is physiological factors, such as exercise is too strenuous, you need to establish a reasonable exercise concept, pay attention to warm up before exercise and stretching after exercise to relieve pain. If it is a pathological cause of muscle strain, then you need to carry out timely imaging examination, you can take non-steroidal anti-inflammatory drugs under the guidance of the doctor, such as ibuprofen, diclofenac sodium extended-release tablets, and so on. If the strain is caused by pathological reasons, you need not to do strenuous exercise as much as possible, and you can use drugs to activate blood circulation and remove blood stasis, such as Qinchuan Tongpaio Tablets, chasing the wind through the bone capsule and so on. Excluding physiological factors, go to the hospital in time to treat the pathological causes, to avoid delaying the treatment of the disease.