Some people will experience pain similar to mild menstrual cramps and the pregnancy products will be expelled, while others will feel a very unbearable level of pain. In most cases, the pain occurs about 20 minutes after taking misoprostol. The pain is paroxysmal and does not last long, and it gradually subsides in about 20 minutes. It is important to observe the amount of vaginal bleeding and to see if any pregnancy products are being discharged along with the vaginal bleeding.