The difference between Veled, or Tenofovir, and Entecavir is mainly due to the different applicability of Entecavir, adverse effects, and contraindications of Entecavir. 1. Applicable people: Entecavir can be used in patients with renal insufficiency, while Tenofovir can be used in pregnant women, and the antiviral effect of Tenofovir is better than that of Entecavir. Tenofovir is used to treat HIV infection and chronic hepatitis B virus infection. Entecavir is used for the treatment of chronic adult hepatitis B with active viral replication, active hepatic histologic lesions or persistently elevated serum alanine aminotransferase. 2. Adverse reactions: Tenofovir has been found to be less susceptible to drug resistance, while Entecavir is more resistant than Tenofovir. Tenofovir can cause weakness, dizziness and headache, diarrhea and abdominal pain and bloating, loss of appetite, nausea and vomiting, pancreatitis, hypophosphatemia, fat accumulation and redistribution, lactic acidosis, hepatomegaly associated with steatosis, etc., respiratory distress, and drug rash. Entecavir can cause diarrhea, nausea, loose stools, delayed menstruation, rash, elevated blood creatinine, and possible abnormalities in white blood cell count, platelet count, hemoglobin, blood urea nitrogen, and blood creatinine indicators. 3. Contraindications: Tenofovir is contraindicated in patients who are hypersensitive to tenofovir or any excipients in the preparation. Entecavir is contraindicated in patients who are allergic to entecavir or any of the ingredients in the preparation. The drug should be applied reasonably according to the doctor’s instructions.