Creutzfeldt-Jakob disease, also known as prion disease, is a chronic progressive infectious disease of the central nervous system and is a zoonotic disease. Its causative agent is prion protein, which has a very strong pathogenic factor, and the prion protein itself has no nucleic acid, but has super infectivity. It is characterized by high temperature resistance, UV resistance, and strong resistance to chemical disinfection, which is difficult to kill by low temperature and freezing, and is very infectious. Patients mainly present with a slow onset of progressive cognitive decline, dementia, myoclonus, and ataxia, often seen after middle age, with a slow onset and an incubation period of up to 30 years in some patients. Creutzfeldt-Jakob disease can be transmitted through contact with bodily fluids, blood or surgical instruments, etc. The prognosis is poor, and many patients die within 1-2 years once the disease has developed.