Penicillin is one of the more commonly used antibiotics in clinical practice. Precautions include skin test, don’t drink, and interval injection with other drugs, etc., as follows: 1. Skin test: Generally speaking, skin test should be performed before injecting penicillin, because some patients are in allergic state to penicillin, and if injected directly without skin test, it may cause drug anaphylaxis, which requires active resuscitation and is more dangerous. If the patient has a negative skin test, it is safer to inject again.2. Don’t drink: Patients should not drink during penicillin injection to avoid the reaction to the drug after drinking, which may cause serious complications such as itching, redness and swelling of the skin, chest tightness, and panic. 3. Inject at intervals with other drugs: When patients are injected with penicillin, it is recommended that they should preferably be spaced with other drugs, or flush the tube before injection, because The patient should pay attention to the review during the active treatment, because the effectiveness of the anti-infection treatment should be objectively analyzed by the results of the review.