All diseases are painful at an advanced stage, and acromegaly also shows painful manifestations at an advanced stage, such as medullary paralysis, difficulty in swallowing and chewing, and shortness of breath. Patients cannot swallow freely and even breathing is very difficult, requiring external help. Difficulty in swallowing requires gastrostomy, and difficulty in breathing requires the application of a ventilator. The quality of life of the patient is definitely reduced compared to normal people, and the patient may also have difficulty in coughing up sputum, with phlegm, mucus, and inability to cough it up, which is very harmful to the quality of life, so it is very painful for the patient. Nowadays medical conditions can help patients to alleviate this difficulty to a certain extent, for example, breathing difficulties can be improved by invasive ventilators to improve coughing and breathing, by reasonable gastric nasal feeding to improve the nutritional status, and by the human eye control device can make patients communicate with the world although they are lying on the hospital bed. The disease basically does not involve the eyes even in the later stages, so the patient can still watch movies and communicate with anyone through the eyes and through relevant computer equipment. In one case in these two years, through active treatment, the patient was able to be pushed by his family to take the ventilator to the park for more than an hour, despite the application of an invasive ventilator, and had a relatively high quality of life. In conclusion, acromegaly is relatively painful in the later stages. If a family member is with the patient, the patient’s pain will be greatly reduced at this time.