Lipoproteins are globular particles formed by the combination of blood lipids and apolipoproteins, and abnormal values may be associated with atherosclerotic disease, diabetes, obesity, and tumors. Lipoproteins are formed by the combination of lipids and apolipoproteins. Lipoproteins are a class of globular particles with a hydrophobic core rich in sterol lipids and triglycerides and a shell composed of proteins, phospholipids, and cholesterol. If lipoprotein abnormalities are present, they are usually accompanied by alterations in lipid composition and protein fractions, and are strongly associated with atherosclerosis, diabetes, obesity, and tumors. Normal lipoprotein levels can be determined clinically by the levels of HDL cholesterol, LDL cholesterol and total cholesterol. If abnormalities occur, it is best to seek prompt medical attention.