It is possible to take amoxicillin for toothache, but it must be noted that if the clinical symptoms of toothache appear, the best way is to go to the professional dentistry to check what causes the toothache, for example, toothache caused by caries, it is necessary to carry out decay and filling treatment for the caries. If the toothache is caused by wisdom tooth pericoronitis, we should treat the wisdom tooth pericoronitis with rinsing and systemic application of medicine combined with tooth extraction. Amoxicillin alone can treat the symptom but not the root cause. Meanwhile, for the bacterial infection in stomatology, amoxicillin has certain effect, but it is better to apply metronidazole and nitroimidazole together to have very good treatment effect on the anaerobic bacterial infection in the oral cavity.