The difference between glans and syphilis is mainly reflected in the means of transmission, lesion sites, causes, symptoms, treatment and other aspects. 1. Different ways of transmission: glans does not spread through sexual contact, while syphilis mainly spreads through sexual contact, mother and child, blood and so on. 2. Different lesion sites: glans mainly involves glans localization and foreskin, while syphilis can invade any organ of the body. 3. Different causes: glansitis is caused by fungi, bacteria and other infectious factors and non-infectious factors such as material stimulation, allergy, trauma, etc., while syphilis is caused by syphilis spirochete infection. 4. Symptoms are different: glans is manifested as redness, swelling, erythema and erosion of the glans skin, accompanied by itching and pain; while syphilis is manifested as a hard chancre, which is a coin-sized painless ulcer with a slightly elevated periphery and a moist center. 5. Treatment is different: the treatment of glans is mainly based on anti-infective treatment, need to drug sensitivity test to determine the sensitive bacteria after treatment, generally a good prognosis; while the treatment of syphilis is mainly applied to penicillin treatment, penicillin allergy can be applied to ceftriaxone, doxycycline, etc., the early stage of syphilis in a timely manner to accept the treatment can be cured, the late stage of syphilis patients usually have a poorer prognosis.