The treatment of chronic inflammation of the mucosa of the ileocecal valve needs to exclude intestinal tuberculosis and Crohn’s disease in order to target the use of drugs, the treatment includes drug therapy and general treatment. 1. Drug therapy: chronic inflammation of ileocecal mucosa is mainly due to the infection of gram-negative bacilli, and the preferred drugs are second- and third-generation cephalosporins and aminoglycosides. When the symptoms are mild, aminoglycoside antibiotics such as amikacin can be used for oral treatment; if the symptoms are more serious, a combination of cephalosporins and aminoglycoside antibiotics should be chosen. The common ones are cefuroxime and amikacin. 2. General treatment:Normally, we should pay attention to develop good living and dietary habits, such as eating less spicy stimulation, too hot, too cold, too hard food and so on. If discomfort occurs, it is recommended to consult a doctor in a timely manner, under the guidance of the doctor to carry out targeted treatment, do not take medication, so as not to delay the condition.