Whether erythema multiforme is serious or not depends on its typing, and patients should seek medical attention in time and be treated under the guidance of doctors. 1. erythema-papular type erythema multiforme: it is edematous erythema with iris-like or target-shaped appearance in the center, which is the most typical manifestation of erythema multiforme, and purpura, blisters and papules may appear. This erythema papulosum type, with mild symptoms for most patients, does not require special treatment and can generally subside in about 2-4 weeks, leaving temporary pigmentation; 2. Blistering-herpetic erythema multiforme: generally the disease is relatively heavy, and the lesions will gradually spread from the distal extremities to the whole body, oral cavity and external genital mucosa, with exudation and erosion, often developing into blisters. Patients need to have the herpes fluid of blisters extracted by doctors to avoid infection after rupture, then apply cold wet compresses with boric acid solution or saline externally, and apply erythromycin ointment locally; 3. Heavy erythema multiforme: generally the condition is very acute and serious, and this kind of heavy erythema multiforme is usually caused by drugs, such as sulfonamide, antipyretic and analgesic, penicillin and other drugs that are easily allergic. Patients with blisters or large blisters on the skin may also be accompanied by headache, high fever, chills and other symptoms, easily combined with bleeding diseases in the oral cavity, eyes and other parts of the body, with a certain rate of death, and should seek medical treatment in time.