Neonatal cardiomyopathy is caused by various factors after birth, such as viral infections and other diseases, resulting in reduced systolic and diastolic function of the child’s heart, which in severe cases can lead to heart failure and severe arrhythmias, resulting in the death of the child. Therefore, once neonatal cardiomyopathy occurs, active treatment should be given. In terms of treatment, the main focus is on myocardial nutrition, anti-inflammatory, cardiac strength, diuretic, such as commonly used drugs such as digoxin, spironolactone, hydrochlorothiazide, sodium fructose phosphate, energy combination, vitamin C, coenzyme Q10 and so on, all of which are cardiac strength, diuretic and myocardial nutrition drugs. If it is due to infectious factors, active treatment can also be given with sensitive antibiotics based on the results of blood culture.