Tightness, distension and foreign body sensation in the throat and esophagus when lifting up the chest may be caused by esophageal foreign body, esophageal tumor, gastroesophageal reflux, etc., which need to be treated with general treatment, medication, surgery, and so on. 1. Foreign body in the esophagus: For example, if there is a history of bone or fish splinter ingestion, attention should be paid to the exclusion of foreign body in the esophagus. Foreign bodies in the esophagus can cause obvious foreign body sensation, and can also cause scratches in the throat and esophagus area, which can be manifested as swelling and pain. The foreign body should be removed by the doctor with the aid of gastroscopy or other tools. 2. Esophageal tumor: for example, esophageal cancer, once diagnosed in early stage, patients should take surgical treatment in time to remove the tumor, and further radiotherapy and chemotherapy can be provided after surgery. 3. Gastroesophageal reflux: it is mainly a series of acid reflux, heartburn, tension and discomfort in the throat and esophagus caused by gastric acid reflux, which needs to be treated with acid-suppressing drugs such as omeprazole, pantoprazole, and gastric power-promoting drugs such as mosapride, itopride, and so on. Chest up when the throat and esophagus tight, swelling and foreign body sensation may also be caused by other reasons, should be timely to the hospital, identify the causes of targeted treatment, medication should be a doctor’s guidance.