Urine protein (++++) indicates a large amount of protein in the urine and is usually caused by kidney disease, most commonly diseases such as nephrotic syndrome or glomerulonephritis. Treatment starts with checking 24h urine protein quantification to assess urine protein leakage. Also rule out secondary kidney damage, such as tumors and kidney damage caused by immune system diseases. After ruling out these diseases, the specific pathological type can be clarified by kidney puncture examination, and different treatment options can be chosen according to different types, for example, hormone therapy can be chosen for microscopic lesion type. Membranous nephropathy requires hormone or immunosuppressive therapy, and the commonly used treatment regimen is prednisone combined with cyclophosphamide, or prednisone combined with tacrolimus. In addition to these oral medications, diet should be based on the principle of low salt, low fat and high quality protein diet to avoid increasing the burden on the kidneys, and pay attention to the prevention of cold and flu to avoid acute kidney injury.