Human immunoglobulin has the effect of enhancing the body’s ability to fight infection and immunomodulation, and commonly used drug side effects include headache, panic, nausea, chills, fever, and malaise. Human immunoglobulin is a drug prepared from healthy human plasma, containing broad-spectrum anti-bacterial, fungal, viral and other pathogens of the IgG antibody, into the human body can rapidly enhance the body’s ability to fight infection and can form a complex immune network and thus have immunomodulatory effects, mostly used in the treatment of primary immunoglobulin deficiency, secondary immunoglobulin deficiency and autoimmune diseases. The drug generally has no significant adverse effects, but individual patients may experience transient headache, panic, nausea, chills, fever, malaise and other adverse effects. Caution should be exercised in the treatment of pregnant women and women who may become pregnant with this drug, and caution should be exercised in patients with severe acid-base balance disorders. Treatment with human immunoglobulin is contraindicated in patients who are hypersensitive to human immunoglobulin or have a history of other severe allergies and in patients with selective lgA deficiency who have anti-lgA antibodies. Drugs need to be used under the guidance of a physician, it is recommended that patients who need to use human immunoglobulin treatment to the relevant departments of the regular hospital for detailed consultation, do not self-medication.