The foramen ovale is a physiologic passageway in the atrial septum of the heart during embryonic life. Foramen ovale failure is defined as the failure of the foramen ovale to fuse at about 1 year of age after birth, and on echocardiography an unclosed foramen ovale of the left and right ventricles may be detected, which may present with either a left-to-right shunt or a right-to-left shunt. Foramen ovale nonocclusion is mostly asymptomatic when the shunt is small, and when a significant shunt occurs, an unexplained stroke or migraine may occur, along with potential symptoms such as syncope, temporary loss of appetite, and sleep apnea. When there is no clinical manifestation of patent foramen ovale, there is no need for special treatment. When there is cerebral ischemia, migraine and other manifestations, aspirin, warfarin and other medications can be taken, and interventional therapy can also be used to block the unclosed patent foramen ovale. Patients with unclosed foramen ovale should go to the hospital in time, complete the examination, assess the severity of the disease, and choose the appropriate treatment under the guidance of the doctor.