Severe brain fatigue is related to the patient’s mental tension and overuse of the brain, which can be relieved by the following methods: First, it is recommended that the patient should be in a relaxed state, and the patient should close his eyes to recuperate, and can use the thumbs of both hands to press and rub the temples, which can relieve the patient’s brain fatigue. Secondly, it is recommended that patients should do aerobic exercise to increase the basal metabolic rate, which can effectively relieve brain fatigue. It is recommended that patients should breathe fresh air outdoors and do walking and running exercises. Thirdly, it is recommended that patients can use drugs to improve cerebral blood supply, which can also relieve brain fatigue, such as flunarizine hydrochloride and ginkgo biloba extract tablets, which can improve the symptoms. Fourthly, patients should usually ensure sufficient sleep, avoid overthinking and stay up late.