Hepatoportal bile duct tumor is usually hepatoportal bile duct cancer, and pancreas needs to be removed to prevent cancer cells from spreading to pancreas when extended radical resection is performed for hepatoportal bile duct cancer. Hepatoportal bile duct cancer is one of the common malignant tumors in biliary system, which has low surgical resection rate, many complications, insensitivity to radiotherapy and poor clinical efficacy, and the 5-year survival rate is only 9%~27%. Hepatoportal cholangiocarcinoma is a kind of cholangiocarcinoma. Currently, radical resection is the only cure for hepatoportal cholangiocarcinoma, and also the only effective treatment for patients to get long-term survival. Standard radical surgery for hilar cholangiocarcinoma consists of hepatic lobectomy and extrahepatic choledochotomy, regional lymph node and nerve plexus contouring and choledocho-jejunostomy. The scope of surgery is mainly based on the location of the tumor, the extent of invasion, and the relationship with blood vessels, and the reasonable scope of surgery should be on the premise of guaranteeing negative bile duct margins and contouring of the regional lymphoid and fatty tissues, as well as trying to preserve the normal liver tissues as much as possible. Extended radical resection is not commonly used and its practical significance is controversial. Hepatoportal cholangiocarcinoma is more common, if there is jaundice and discomfort in the hepatobiliary region, one should consult the doctor as soon as possible, follow the doctor’s advice and treat it as early as possible.