As early as 1992, the World Health Organization issued the famous Victoria Declaration at the International Conference on Heart Health held in Victoria, Canada. The Declaration proposes to build a golden bridge between scientific arguments and the public, and the four cornerstones of this golden bridge are: reasonable diet, moderate exercise, smoking cessation and alcohol restriction, and psychological balance.” The word “alcohol” is really memorable. From that time onwards, the saying that drinking alcohol in moderation is good for health has become a folklore. I have personally seen a friend from the original very little alcohol, and then a few cups a day, said “soften blood vessels, stroke prevention”, I think this is purely a monk read a distorted version of the views and behavior, I really do not agree. In 2002, the World Health Organization issued a report on cancer surveillance, pointing out that “attention should be paid to diet and the role of alcohol in carcinogenesis”, and reminding people that “alcohol” may cause cancer, and that only low quality alcohol, such as wine, can reduce the risk of cardiovascular disease and is beneficial to health; however, excessive consumption of alcohol can reduce the risk of cardiovascular disease and is beneficial to health. Only low-quality alcohol, such as wine, can reduce the risk of cardiovascular disease and is beneficial to health. However, excessive alcohol consumption, especially alcoholism, can lead to alcohol poisoning, which can cause serious damage to health and induce cancer. This is somewhat confusing. The right way to look at alcohol and drinking is a scientific issue, a social issue, and a matter of human behavior. Similar to smoking, drinking large quantities of alcohol over a long period of time is addictive, and once addicted, the act of drinking itself is difficult to reverse, and the damage done to the body is difficult to correct. One of the problems of inducing cancer becomes very prominent. So alcoholism or addiction must be a self-injurious behavior. The harm done by alcohol to the human body should be explored in terms of both “quantity” and “quality”. So far, the most fully researched alcoholic liver disease, including liver cancer, because ethanol, the main component of alcohol, needs to be metabolized in the liver, and the metabolism of ethanol in the liver of different individuals is strong and weak, so even if you drink the same amount of alcohol, the consequences can be significantly different. Domestic authoritative textbooks or authoritative experts are more consistent point of view is: there is a long-term history of alcohol consumption, generally more than 5 years, according to the amount of ethanol (one or two height of white wine is about 25 grams of ethanol) calculation, in the male is greater than or equal to 40 grams per day, the female is greater than or equal to 20 grams per day; or 2 weeks with a large amount of alcohol consumption history, the equivalent of the amount of ethanol is greater than 80 grams per day. The diagnosis of alcoholic liver disease is established when liver damage occurs under these circumstances and other causes of liver disease have been ruled out. The most serious form of alcoholic liver disease is “alcoholic cirrhosis combined with liver cancer”. In western countries, liver cancer caused by alcoholism accounts for the first place of primary liver cancer, while in China, due to the high incidence of hepatitis B, alcoholic liver cancer is still in the secondary position, but with the effective control of hepatitis B, the incidence of alcohol-induced primary liver cancer and the absolute value of the incidence of liver cancer have been on the rise year by year. What needs more attention is that if chronic viral hepatitis patients abuse alcohol, the incidence of cirrhosis and hepatocellular carcinoma within 5 to 10 years is more than ten times higher than that of non-alcoholics. Rough statistics have been done among patients with chronic hepatitis B, and it is found that among several pairs of brothers with chronic hepatitis B, alcoholics tend to die of cirrhosis and liver cancer before the age of 55, and those who can survive and get further treatment are often the brothers who do not drink alcohol at all. It can be seen that patients suffering from viral hepatitis, if they are still addicted to alcohol, it can be said to be worse for the liver, is extremely irresponsible behavior for their health and life. In the early years, a scholar in China studied the effect of a famous domestic spirit on the liver of animals, and came to the conclusion that the spirit is not easy to cause liver damage and cirrhosis, which has triggered extensive debate in the academic community. In fact, the researcher failed to draw the attention of his peers to an important description: his conclusion was based on the use of ordinary, poor-quality liquors available on the market as a control group, which was a “comparative” result. This suggests that, again, it is important to control not only the dosage but also the quality of the alcohol consumed. Alcoholic beverages in the fermentation or distillation process not only produces ethanol, but also produces polycyclic aromatic hydrocarbons, including benzo(a)pyrene and benzo(a)anthracene, and may even be mixed with asbestos and other chemicals, which are strong carcinogens, the more rough the production process of alcohol, the higher the content of these carcinogens, and the greater the harm caused by long-term ingestion of these carcinogens, that is to say, the more powerful carcinogenicity. Poor quality alcoholic beverages also contain more formaldehyde. Formaldehyde and ethanol metabolite acetaldehyde, is a molecular cross-linking agent, in vitro can promote the aging of macromolecular substances, in vivo will inevitably promote the aging of vital substances, and thus is also an important factor in promoting cancer. Besides, research has confirmed that alcohol can dissolve many carcinogenic substances, which can easily break through the protective barrier of human mucous membrane and be absorbed by tissues to cause cancer; alcohol can also induce the activity of certain enzymes in the body, such as polycyclic aromatic hydrocarbon activating enzyme, benzopyrene hydroxylase, etc., and the enhanced activity of these enzymes accelerates the production or activity of such carcinogenic substances, which pushes forward the cancerous process; of course, alcohol itself can also promote cell mutation, which is an important factor in promoting carcinogenesis. Of course, alcohol (ethanol) itself can also promote cell mutation, which is also one of the important reasons why alcoholics are prone to cancer. In addition to the aforementioned liver cancer, it is not an exaggeration to say that wherever alcohol goes, it may sweep away all normal tissue cells in contact with it. For example, alcohol can cause cancer of the oral mucosa and cancer of the pharynx, of which the incidence rate of laryngeal cancer in alcoholics is 10 times higher than that in non-alcoholics! Alcoholics have a 20 times higher incidence of esophageal cancer than non-alcoholics! Stomach and colon cancers are also associated with long-term and heavy drinking. No matter how you look at it, alcoholism is a very bad habit, and we shouldn’t drink alcohol every day in order to so-called soften blood vessels, prevent cardiovascular and cerebrovascular diseases, or even to prolong our lives. For people with basic liver diseases, drinking alcohol not only harms the liver, but also because the detoxification and metabolism functions of the liver have been reduced, drinking alcohol is more likely to trigger alcohol-induced lesions in other organs, including the development of cancer. Let’s not drink!