Long time not on the large can be through dietary treatment such as eating more leeks, or medication such as ondansetron and other ways to relieve and treat. 1. Dietary treatment: daily diet should pay attention to more water intake, drink more warm water; avoid chili peppers, fried chicken, pickles, alcohol, strong tea and other stimulating food intake, so as not to stimulate the gastrointestinal mucosa and aggravate the burden on the gastrointestinal tract, resulting in abdominal distension, constipation, etc.; eat more dietary fiber-rich foods, such as sweet potatoes, leeks, etc., in order to promote bowel movements. 2. Pharmacotherapy: gastrointestinal stimulants, osmotic laxatives, intestinal microecological agents, etc. can be used as prescribed by the doctor. (1) Promote gastrointestinal dynamics agent: such as ondansetron, Prucalopride, metoclopramide, etc., can promote gastrointestinal movement, enhance gastric emptying and promote food in the digestive tract forward, thereby enhancing food digestion and absorption, so that feces can be easily discharged. (2) Osmotic laxatives: Lactulose, polyethylene glycol and other laxatives can be used to increase the osmotic pressure in the intestinal tract, stimulate the intestinal wall to produce stool and lubricate the intestinal tract to promote the discharge of feces from the body. (3) Intestinal microecological agents: such as Bifidobacterium lactis trilobacteria, etc., can inhibit the reproduction of intestinal harmful bacteria and promote the growth of beneficial bacteria, thus regulating the balance of intestinal flora and improving the symptoms of constipation and diarrhea. It is recommended that the patient should consult a doctor in time in order to make a clear diagnosis and carry out targeted treatment. In addition, all of the above drugs should be taken under the guidance of a doctor and should not be used without authorization.