Nosebleed is one of the common clinical symptoms, which may be caused by too dry environment, or it may be caused by deviated nasal septum, leukemia and other diseases. According to the severity of the bleeding, commonly used drugs to stop bleeding include thrombin, phenolsulfonyl ethylamine, aminocaproic acid, etc. Patients are advised to follow the doctor’s instructions for medication. 1. Thrombin: commonly used dosage form is lyophilized powder, which is used for hemostasis of small blood vessels that are not easy to be ligated in surgery, gastrointestinal bleeding and traumatic bleeding. When thrombin is used for nosebleed caused by deviated nasal septum, it can be used to stop bleeding by spraying the dry powder on the wound surface, so as to make the blood coagulate and achieve the purpose of hemostasis. 2. Phenolsulfonyl ethylamine: as a hemostatic drug, it can be used to prevent and control bleeding before and after various surgeries, and can also be used for platelet dysfunction, blood vessel brittleness caused by bleeding, and can also be used for vomiting blood, blood in the urine and so on. Phenosulfanilamide can enhance platelet aggregation and adhesion, promote platelet release of coagulant active substances, for leukemia-induced nosebleed has a certain hemostatic effect. 3. Aminocaproic acid: it is mainly used for the prevention and treatment of various bleeding caused by hyperfibrinolysis, and can be used as auxiliary treatment for leukemia patients with nosebleeds. The immediate hemostatic effect of this drug is poor, for acute hemorrhage should be used together with other hemostatic drugs. In addition, appropriate administration of vitamin K, vitamin C and other nutrients is also effective in relieving nosebleeds. Patients with nosebleeds should consult a doctor in time to find out the cause of the disease and treat the primary disease, and should not blindly use drugs to stop bleeding, so as not to delay the condition or serious adverse reactions.