The time for neocollins to turn negative is usually around 10 to 14 days, but this cannot be generalized and needs to be assessed based on the patient’s condition, physical fitness, age, etc. Moreover, antigenic turnover is usually earlier than nucleic acid turnover, which may be as early as 5-7 days. Usually, after patients are infected with the new coronavirus, there is an incubation period of 1 to 14 days, mostly 3 to 7 days. Most patients present with fever, dry cough and fatigue. Some patients have loss of smell and taste as the first symptom, and some patients may have no obvious clinical symptoms. At present, the main epidemic strain is Omicron, and the infection is mainly in mild and asymptomatic infected patients. At present, home isolation is generally adopted for asymptomatic infected patients and mild cases with home isolation conditions. Symptomatic treatment and disease monitoring are required during isolation management. If the new crown does not turn negative for a long time, and the symptoms gradually worsen and are not relieved, it is recommended to consult a doctor in time. Tips] In this article, “new coronavirus pneumonia” and “new coronavirus pneumonia” have been renamed to “new coronavirus infection” on December 26, 2022, as announced by the National Health Commission.