Redness and itchiness all over the body after drinking alcohol is considered to be due to the lack of acetaldehyde dehydrogenase in the body. The lack of acetaldehyde dehydrogenase causes the body to be unable to rapidly break down and metabolize alcohol, which increases the burden on the liver, resulting in redness and itchiness after drinking. There are individual differences in the amount of acetaldehyde dehydrogenase produced. Some people can produce more acetaldehyde dehydrogenase and will not have red face and skin after drinking, while some people are congenitally deficient in acetaldehyde dehydrogenase and will easily have red face, red skin and itchy skin after drinking. It is also necessary to rule out the presence of allergies and the presence of other drugs or foods taken before and after drinking alcohol, which can lead to toxic reactions. In clinical practice, disulfiram-like reactions occur most often when alcohol is consumed after the use of cephalosporins.