Urethral redness and swelling is considered to be related to urethritis, glans, allergy, etc. Patients can use levofloxacin hydrochloride cream, miconazole ointment and so on. 1. Urethritis: Urethritis is mainly anti-infective treatment, gonorrhea urethritis patients often oral or intramuscular injection of cefixime, levofloxacin, ceftriaxone sodium and other antibiotics. Some patients may apply topical levofloxacin hydrochloride cream, ciprofloxacin cream and so on. Non-gonococcal urethritis can be treated with azithromycin, minocycline and other drugs as prescribed by the doctor. 2. Glans: Candida glans patients can follow the doctor’s instructions with miconazole ointment, clotrimazole ointment and other medications, anaerobic infections caused by glans patients need to use metronidazole, itraconazole treatment. Aerobic bacterial infections caused by glans can be used betamethasone cream or oral erythromycin, clavulanic acid and other drugs. 3. Allergy: clear allergy caused by urethral erythema, can follow the doctor’s instructions with mometasone furoate ointment, tacrolimus cream and other drugs to achieve the therapeutic purpose, so as to alleviate the phenomenon of erythema. It is recommended that people with urethral redness and swelling should follow the doctor’s instructions to use medication, and should not use medication indiscriminately. Pay attention to daily skin care, drink more water, urinate regularly.