In renal insufficiency, glomerular filtration rate decreases and metabolic waste elimination is impaired, resulting in elevated urea nitrogen. First of all, the cause of renal insufficiency should be clearly defined, and targeted treatment should be carried out according to different causes, such as medication, surgical treatment, renal replacement therapy, and so on. First of all, the cause of renal insufficiency should be clearly defined. If it is caused by urinary obstruction, it is necessary to release the obstruction, such as extracorporeal shock wave lithotripsy; if it is caused by gastrointestinal hemorrhage, it is necessary to give blood transfusion; if it is caused by glomerulonephritis, it can be orally administered with prednisone acetate, cyclophosphamide, etc. If it is caused by diabetic nephropathy, which is the cause of chronic renal insufficiency, resulting in the elevation of urea nitrogen, then it is possible to orally administered with nephrokinetic. If the effect of drugs and surgery is not good, renal replacement therapy is feasible when necessary. The above medication should be taken under the guidance of physicians, and should not be used without authorization to avoid aggravating the condition. After renal insufficiency with elevated urea nitrogen, it is recommended to visit the hospital in time to find out the cause of the problem, and then treat the problem under the guidance of specialists.