Leg swelling caused by hypothyroidism can be treated with levothyroxine sodium tablets and other treatments. Hypothyroidism causes non-sagging edema due to the accumulation of large amounts of hyaluronic acid, mucopolysaccharides, chondroitin sulfate and water in the intercellular fluid as a result of insufficient secretion of thyroid hormones. Treatment can be replaced with levothyroxine sodium tablets, dietary supplements rich in iodine, such as seaweed, kelp, and proper elevation of the legs to promote blood reflux to reduce edema. Hypothyroidism caused by mucous edema can also occur in many visceral parts, such as the mucous membrane of the digestive tract and the plasma membrane cavity, such as the thoracic cavity, abdominal cavity, pericardium can appear in the accumulation of fluids, known as visceral mucous edema, the serious can occur mucous edema coma, the condition of the critical condition, it must be treated in a timely manner. It is recommended that patients with leg swelling caused by hypothyroidism should go to the hospital in time and be treated under the guidance of a doctor.