The chance of detecting gastric cancer by gastroscopic biopsy varies greatly depending on the region and hospital, and it does not mean that having a biopsy means that it may be gastric cancer. On one hand, gastroscopy biopsy is needed to further clarify the nature of the lesion through histological examination, for example, is gastritis atrophic or non-atrophic? Are the polyps, ulcers or masses benign or malignant? What type of tissue is present? On the other hand, the severity of the lesion also needs to be clarified, such as how severe is atrophic gastritis? Is the inflammation active, that is, is it progressing? Is it accompanied by precancerous lesions such as heterogeneous hyperplasia and intestinal metaplasia? Then again, there are some lesions that do not require a determination of the nature of the lesion, but do they require a determination of the presence of H. pylori infection? For example, in patients with gastritis and duodenal ulcer, special staining of the gastric mucosa can determine the presence or absence of H. pylori infection. All of these conditions require gastroscopic biopsy, and cancer is just one of the many types of disease. Gastroscopic biopsy is an important tool for cancer screening. Sometimes some small lesions are difficult to identify through visual observation, but more and clearer information can be found during pathological examination. It is the “gold standard” of diagnosis because of pathological examination. Therefore, gastroscopy biopsy is an important tool to diagnose cancer, but it is not necessary to do biopsy only for cancer.