The need for biopsy after gastroscopy depends on the need of the condition and is not an arbitrary choice, so it is difficult to count the number of people. During gastroscopy the doctor will carefully observe the esophageal, gastric and duodenal mucosa. Some lesions can be clarified by visual observation and can be removed without biopsy. However, some lesions need to be biopsied and small pieces of mucosal tissue are taken with special biopsy forceps and observed by the pathologist under a microscope after special staining and magnification of the mucosal tissues and cells. Biopsy pathology is needed to clarify the nature of the lesion on the one hand, for example, is gastritis atrophic or non-atrophic? Are the polyps, ulcers or masses benign or malignant, and what type of tissue are they? On the other hand, the severity of the lesion also needs to be clarified, such as how severe is atrophic gastritis? Is the inflammation active, that is, is it progressing? Is it accompanied by precancerous lesions such as heterogeneous hyperplasia and intestinal metaplasia? Then again, there are some lesions that do not require a determination of the nature of the lesion, but do they require a determination of the presence of H. pylori infection? For example, in patients with gastritis and duodenal ulcer, special staining of the gastric mucosa can determine whether there is H. pylori infection, and the drug resistance of H. pylori can also be checked, and the sensitivity of the patient to certain drugs can also be determined so that the treatment strategy can be formulated. All of these conditions need to be dealt with by biopsy. In summary, the need for biopsy after gastroscopy depends on the need for the condition, and swellings, as well as ulcerative lesions, basically require a mucosal biopsy. A subset of inflammatory lesions also require biopsy pathology.