High creatinine is divided into physiological causes and pathological causes, physiological causes include strenuous exercise, eating a large amount of meat, etc. Usually, it will return to normal after resting and adjusting the diet. Pathological causes include acute and chronic kidney diseases, chronic glomerulonephritis, diabetic nephropathy and other diseases, which need to choose the appropriate treatment plan according to the original disease. Physiological causes: A transient increase in creatinine may occur after strenuous exercise or eating a large amount of meat, which will return to normal after rest and dietary adjustment. Pathological causes: seen in acute and chronic kidney disease, chronic glomerulonephritis, diabetic nephropathy and other diseases. Acute kidney disease is divided into pre-renal, renal and post-renal. Pre-renal such as creatinine elevation due to insufficient renal perfusion, treatment is based on fluid replacement; post-renal such as stones, treatment is based on removal of obstruction. Renal such as drug-induced, need to stop drugs in time, symptomatic supportive treatment. Elevated creatinine caused by chronic kidney disease includes allopathic treatment, general supportive treatment, immunosuppressive treatment, integrated management of chronic kidney disease and replacement therapy according to the type and stage of the disease. Chronic glomerulonephritis causing high creatinine, treatment is based on dietary control, active blood pressure lowering and urine protein lowering, etc. Hormones and/or immunosuppressants are used according to the situation. The treatment of diabetic nephropathy is based on dietary control, active lowering of glucose, lowering of blood pressure and lowering of lipids. Elevated creatinine is recommended to go to the hospital in time, find out the cause under the guidance of specialized physicians, and follow the doctor’s instructions for treatment.