Intracranial tumors are currently not particularly effective with chemotherapy, i.e., they cannot be cured because of the blood-brain barrier, which prevents most drugs from entering the skull at the time of implementation. Intracranial tumors are divided into primary tumors and secondary tumors, or called metastatic tumors. Primary tumors are commonly gliomas, lymphomas, germ cell tumors, and metastatic tumors are commonly primary such as lung cancer, breast cancer, melanoma, and ovarian. For intracranial tumors, whether primary or secondary, surgery and radiotherapy are the mainstays. Because of the role of the blood-brain barrier, the effect of chemotherapy in the treatment of intracranial tumors is relatively limited, but for primary tumors, such as intracranial germ cell tumors and lymphomas, they are still very sensitive to chemotherapeutic drugs. In younger patients, such as children or adolescents, especially predevelopmental children, radiotherapy may affect growth or development. Some scholars have explored whether chemotherapy can be applied, and a small sample of data shows that it is effective for intracranial tumors, but the efficacy of the drug is not particularly ideal for long-term survival, and the side effects are more obvious after application. Therefore, the mainstream viewpoint is still that chemotherapy alone cannot be used as the standard treatment for intracranial tumors, and surgery or radiotherapy is still the main treatment means.