Generally, it is not recommended to take multiple medications together as some chemical reactions between the medications may cause one harm to the body. However, there are some medications that produce good results when taken in combination and can be used under a doctor’s supervision. Some drugs can be very risky when taken together. For example, aspirin should be avoided with ibuprofen, which can increase the risk of bleeding. Some medications taken together can interfere with their effectiveness. For example, acidic medications such as gluconic acid and citric acid are much less effective when taken with alkaline medications such as aluminum hydroxide and soda tablets. Some drugs work well in combination, but they must be taken under a doctor’s supervision. For example, the four combination of drugs for the treatment of Helicobacter pylori, you can choose omeprazole, bismuth potassium citrate, amoxicillin, metronidazole combination. There are also some drugs to take time is different, for example, aluminum thioglycollate should be taken one hour before meals and at night before going to bed, such as teprenone, the two for different diseases and the time to take the drug has strict requirements, so it should not be taken at the same time. To summarize, some drugs are prohibited to take at the same time, some drugs can be carefully combined under the guidance of a doctor.